A Short History Of The Drug Receptor Concept
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| Author | : C. Prüll |
| Publisher | : Springer |
| Total Pages | : 248 |
| Release | : 2009-06-25 |
| Genre | : Science |
| ISBN | : 0230583741 |
The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century.
| Author | : Janet L. Stringer |
| Publisher | : McGraw Hill Professional |
| Total Pages | : 254 |
| Release | : 2011-03-11 |
| Genre | : Medical |
| ISBN | : 0071769420 |
A time-saving, stress-reducing approach to learning the essential concepts of pharmacology Great for USMLE review! "This could be a very useful tool for students who struggle with understanding the most basic concepts in pharmacology for course and licensure examinations. 3 Stars."--Doody's Review Service Basic Concepts in Pharmacology provides you with a complete framework for studying -– and understanding -- the fundamental principles of drug actions. With this unique learning system, you’ll be able to identify must-know material, recognize your strengths and weaknesses, minimize memorization, streamline your study, and build your confidence. Basic Concepts in Pharmacology presents drugs by class, details exactly what you need to know about each class, and reinforces key concepts and definitions. With this innovative text you’ll be able to: Recognize the concepts you truly must know before moving on to other material Understand the fundamental principles of drug actions Organize and condense the drug information you must remember Review key information, which is presented in boxes, illustrations, and tables Identify the most important drugs in each drug class Seven sections specifically designed to simplify the learning process and help you gain an understanding of the most important concepts: General Principles Drugs That Affect the Autonomic Nervous System Drugs That Affect the Cardiovascular System Drugs That Act on the Central Nervous System Chemotherapeutic Agents Drugs That Affect the Endocrine System Miscellaneous Drugs (Includes Toxicology and Poisoning)
| Author | : Richard B. Silverman |
| Publisher | : Elsevier |
| Total Pages | : 650 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0080513379 |
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
| Author | : Viviane Quirke |
| Publisher | : Peter Lang |
| Total Pages | : 500 |
| Release | : 2010 |
| Genre | : Business & Economics |
| ISBN | : 9783039109203 |
One of the most striking features of the twentieth century has been the rapid growth of the pharmaceutical industry and the large increases in the use and consumption of its products. This trend began in the first half of the century, but accelerated most sharply after the Second World War, when the creation of national systems of healthcare created mass markets for drugs. The industry then assumed a major economic, social and political significance, and became one of the most highly regulated sectors of the economy, attracting the attention of industry analysts as well as academics. This volume brings together a collection of papers exploring and reflecting upon some of the significant strands in the current studies of pharmaceuticals in the twentieth century. They touch upon many of the issues that are matters of concern and debate today, and their international and multidisciplinary approaches enrich our understanding of an object, of an industry, and of a process that are at the heart of our highly medicalized contemporary societies.
| Author | : Niels Bindslev |
| Publisher | : CRC Press |
| Total Pages | : 847 |
| Release | : 2017-02-10 |
| Genre | : Medical |
| ISBN | : 1351660578 |
Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.
| Author | : Alex S. Evers |
| Publisher | : Cambridge University Press |
| Total Pages | : 2902 |
| Release | : 2011-03-10 |
| Genre | : Medical |
| ISBN | : 1139497022 |
In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
| Author | : Mariana Spetea |
| Publisher | : MDPI |
| Total Pages | : 358 |
| Release | : 2020-12-18 |
| Genre | : Medical |
| ISBN | : 3036500464 |
The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
| Author | : Wolfgang A. Ritschel |
| Publisher | : |
| Total Pages | : 616 |
| Release | : 1992 |
| Genre | : Medical |
| ISBN | : |
| Author | : John C. Foreman |
| Publisher | : CRC Press |
| Total Pages | : 314 |
| Release | : 2010-09-10 |
| Genre | : Medical |
| ISBN | : 1420052551 |
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classica
| Author | : Chris J. van Boxtel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 738 |
| Release | : 2001-11-28 |
| Genre | : Medical |
| ISBN | : 9780471899273 |
This is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs but in this context also the social impact which drugs have in modern societies is highlighted. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book * Covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases * Gives guidance on how doctors should act so that drugs can be used effectively and safely * Encourages the rational use of drugs in society This book brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.
