A Review Of The Recommendations For The Physical Dosimetry Of Boron Neutron Capture Therapy Bnct
Download A Review Of The Recommendations For The Physical Dosimetry Of Boron Neutron Capture Therapy Bnct full books in PDF, epub, and Kindle. Read online free A Review Of The Recommendations For The Physical Dosimetry Of Boron Neutron Capture Therapy Bnct ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Wolfgang A.G. Sauerwein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 545 |
| Release | : 2012-11-05 |
| Genre | : Medical |
| ISBN | : 3642313345 |
Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
| Author | : A.H. Soloway |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 872 |
| Release | : 1993 |
| Genre | : Gardening |
| ISBN | : 9780306445675 |
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
| Author | : Narayan S Hosmane |
| Publisher | : World Scientific |
| Total Pages | : 271 |
| Release | : 2012-03-07 |
| Genre | : Science |
| ISBN | : 9814462187 |
The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.
| Author | : Evamarie Hey-Hawkins |
| Publisher | : John Wiley & Sons |
| Total Pages | : 490 |
| Release | : 2018-07-23 |
| Genre | : Science |
| ISBN | : 1119275555 |
Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
| Author | : M. Frederick Hawthorne |
| Publisher | : Springer |
| Total Pages | : 1389 |
| Release | : 2013-11-11 |
| Genre | : Medical |
| ISBN | : 1461512859 |
Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
| Author | : U.S. Atomic Energy Commission |
| Publisher | : |
| Total Pages | : 856 |
| Release | : 1966 |
| Genre | : Neutron sources |
| ISBN | : |
| Author | : Said F. Mughabghab |
| Publisher | : Elsevier |
| Total Pages | : 1373 |
| Release | : 2006-04-04 |
| Genre | : Science |
| ISBN | : 0080461069 |
The Atlas of Neutron Resonances provides detailed information on neutron resonances, thermal neutron cross sections, and average resonance properties which are important to neutron physicist, astrophysicists, solid state physicists, reactor engineers, scientists involved in activation analysis, and evaluators of neutron cross sections. · Compilation and evaluation of the world's thermal neutron cross-sections and resonance parameters for neutron physicists, reactor engineers, and neutron evaluators.· Compilation and evaluation of coherent scattering lengths for solid state physicists and evaluators· Compilation and evaluation of average 30-keV capture cross sections for astrophysicists.· Nuclear level density parameters derived from average spacings of neutron resonances following a new approach (new feature for this edition).· Brief review of sub-threshold fission.· Comparisons of optical model predictions with neutron strength function data and scattering lengths.· Estimation of average E1 radiative widths on the basis of the generalized Landau-Fermi liquid model (a new feature for this edition).
| Author | : Lennart Lindborg |
| Publisher | : CRC Press |
| Total Pages | : 204 |
| Release | : 2020-10-02 |
| Genre | : |
| ISBN | : 9780367868925 |
Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and health physics courses and by Master's and PhD students. In addition to serving as an introductory text to the field for graduate students, this book will also be of interest as a teaching and reference resource for graduate supervisors and established researchers. Drs. Lennart Lindborg and Anthony Waker have spent a life-time career in experimental microdosimetry research in academic, industrial and regulatory environments and have observed the development of the field from its early days as a recognized discipline; they bring to this book particular knowledge and experience in the design, construction, operation and use of tissue equivalent gas ionization counters and chambers.
| Author | : Ping Xia, PhD |
| Publisher | : Springer Publishing Company |
| Total Pages | : 274 |
| Release | : 2015-09-08 |
| Genre | : Medical |
| ISBN | : 161705240X |
This guide & companion to the Radiation Oncology Self-Assessment Guide is a comprehensive physics review for anyone in the field of radiation oncology looking to enhance their knowledge of medical physics. It covers in depth the principles of radiation physics as applied to radiation therapy along with their technical and clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly ìflash cardî question and answer format with over 800 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The Guide is comprised of 14 chapters that lead the reader through the radiation oncology physics field, from basic physics to current practice and latest innovations. Aspects of basic physics covered include fundamentals, photon and particle interactions, and dose measurement. A section on current practice covers treatment planning, safety, regulations, quality assurance, and SBRT, SRS, TBI, IMRT, and IGRT techniques. A chapter unique to this volume is dedicated to those topics in diagnostic imaging most relevant to radiology, including MRI, ultrasound, fluoroscopy, mammography, PET, SPECT, and CT. New technologies such as VMAT, novel IGRT devices, proton therapy, and MRI-guided therapy are also incorporated. Focused and authoritative, this must-have review combines the expertise of clinical radiation oncology and radiation physics faculty from the Cleveland Clinic Taussig Cancer Institute. Key Features: Includes more than 800 questions with detailed answers and rationales A one-stop guide for those studying the physics of radiation oncology including those wishing to reinforce their current knowledge of medical physics Delivered in a ìflash cardî format to facilitate recall of key concepts and data Presents a unique chapter on diagnostic imaging topics most relevant to radiation oncology Content provided by a vast array of contributors, including physicists, radiation oncology residents, dosimetrists, and physicians About the Editors: Andrew Godley, PhD, is Staff Physicist, Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland OH Ping Xia, PhD, is Head of Medical Physics and Professor of Molecular Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
| Author | : Waldemar H Scharf |
| Publisher | : World Scientific |
| Total Pages | : 342 |
| Release | : 2001-08-17 |
| Genre | : Science |
| ISBN | : 9814491667 |
Hadronic radiotherapy uses particle beams to treat tumors located near critical body structures and tumors that respond poorly to conventional photon and electron beam radiotherapy. Initial research in hadronic radiotherapy was performed using accelerators built for physics research. The good results of the proton and ion therapy programs have enhanced the tendency to use protontherapy as a routine method. There are about 20 working protontherapy facilities (first, second and third generation) and more than 30 centers are planned.This book presents the first comprehensive overview of the field with a discussion on the fundamental basis of particle physics and radiobiology, as well as review of clinical and technical specifications and designs for proton radiotherapy. In particular, the current designs of proton and heavy ion accelerators, beam delivery systems, gantries, beam monitoring and dosimetry systems, control and safety systems, patient positioning and immobilization devices, and ancillary treatment facilities are widely discussed.
