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| Author | : Greg Gibson |
| Publisher | : Sinauer |
| Total Pages | : 0 |
| Release | : 2009-04-20 |
| Genre | : Science |
| ISBN | : 9780878932368 |
An accessible introduction to the field of genome science, it explains bioinformatic principles and experimental strategies alongside experimental methods. This edition has been updated to include the latest developments in next generation sequencing, high-volume genotyping and expression profiling, and advances in metabolomics.
| Author | : Stephen M. Roth |
| Publisher | : Human Kinetics |
| Total Pages | : 198 |
| Release | : 2007 |
| Genre | : Health & Fitness |
| ISBN | : 9780736063432 |
The text maintains a practical focus while providing updates on current research findings and exploring how genetics may affect clinical practice and sport performance training.
| Author | : Nessa Carey |
| Publisher | : Icon Books |
| Total Pages | : 376 |
| Release | : 2015-03-05 |
| Genre | : Science |
| ISBN | : 184831826X |
From the author of the acclaimed The Epigenetics Revolution (‘A book that would have had Darwin swooning’ – Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions – 98% of the human genome – were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself – and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.
| Author | : Marjorie A. Hoy |
| Publisher | : Elsevier |
| Total Pages | : 569 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483293718 |
Developed as an introduction to new molecular genetic techniques, Insect Molecular Genetics also provides literature, terminology, and additional sources of information to students, researchers, and professional entomologists. Although most molecular genetics studies have employed Drosophila, this book applies the same techniques to other insects, including pest insects of economic importance. As a text, as a reference, as a primer, and as a review of a vast and growing literature, Insect Molecular Genetics is a valuable addition to the libraries of entomologists, geneticists, and molecular biologists. - Features offered by this unique reference source: Detailed illustrations - Suggested readings at the end of each chapter - Glossary of molecular genetic terms
| Author | : Donald Voet |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1526 |
| Release | : 2010-12-01 |
| Genre | : Science |
| ISBN | : 0470570954 |
The "Gold Standard" in Biochemistry text books, Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
| Author | : Matt Ridley |
| Publisher | : Harper Collins |
| Total Pages | : 370 |
| Release | : 2013-03-26 |
| Genre | : Science |
| ISBN | : 0062253468 |
“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New Yorker The genome's been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the future Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.
| Author | : Greg Gibson |
| Publisher | : Sinauer Associates Incorporated |
| Total Pages | : 378 |
| Release | : 2004-01-01 |
| Genre | : Science |
| ISBN | : 9780878932320 |
A Primer of Genome Science bridges the gap between standard genetics textbooks and highly specialized, technical, and advanced treatments of the subdisciplines. It provides an affordable and up-to-date introduction to the field that is suited to advanced undergraduate or early graduate courses.
| Author | : Dr. Euan Angus Ashley |
| Publisher | : Celadon Books |
| Total Pages | : 221 |
| Release | : 2021-02-23 |
| Genre | : Science |
| ISBN | : 1250234972 |
In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.
| Author | : J.N. Housby |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 161 |
| Release | : 2005-12-20 |
| Genre | : Science |
| ISBN | : 0306475952 |
76 2. Short Oligonucleotide Mass Analysis 76 2. 1. Method Outline 76 2. 2. Design of PCR Primers and Fragments for Analysis 78 2. 3. Typical PCR Reaction Conditions 79 3. Electrospray Ionisation Mass Spectrometry 79 Formation of Ions 3. 1. 79 3. 2. Tandem Mass Spectrometry 79 3. 3. Typical ESI-MS Settings for SOMA 80 4. Purification Procedures 80 4. 1. Phenol/Chloroform Extraction and Ethanol Precipitation 80 4. 2. In-line HPLC Purification 81 5. Genotyping Using SOMA 81 5. 1. APC Genotyping in Human Subjects 81 5. 2. APC Genotyping in Min Mice 85 5. Mutation Detection Using SOMA 86 6. 1. Analysis of p53 Mutations in Liver Cancer Patients 86 6. 1. 1. p53 Mutations in Liver Tumours 87 6. 1. 2. p53 Mutations in Plasma Samples 88 7. Advantages and Disadvantages of SOMA 89 8. Future Perspectives 90 9. Acknowledgements 91 10. References 91 CHAPTER 7 WV. Bienvenut, M. Müller, PM. Palagi, E. Gasteiger, M. Heller, E. Jung, M. Giron, R. Gras, S. Gay, PA. Binz, G J. Hughes, JC. Sanchez, RD. Appel, DF. Hochstrasser Proteomics and Mass Spectrometry: Some Aspects and Recent Developments 1. Introduction to Proteomics 93 2. Protein Biochemical and Chemical Processing Followed by Mass Spectrometric Analysis 94 2. 1. 2-DE Gel Protein Separation 95 Protein Identification Using Peptide Mass Fingerprinting and Robots 96 2. 2. 2. 2. 1. MALDI-MS Analysis 98 2. 2. 2. MS/MS Analysis 102 Improvement of the Identification by Chemical Modification of Peptides 106 2. 2. 3.
