A Modified Succession Procedure For Group Sequential Clinical Trials
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Proceedings of the Biometrics Section
| Author | : American Statistical Association. Biometrics Section |
| Publisher | : |
| Total Pages | : 462 |
| Release | : 1996 |
| Genre | : Biometry |
| ISBN | : |
Statistical Aspects Of The Design And Analysis Of Clinical Trials (Revised Edition)
| Author | : Brian S Everitt |
| Publisher | : World Scientific |
| Total Pages | : 338 |
| Release | : 2004-02-26 |
| Genre | : Medical |
| ISBN | : 1783260777 |
Fully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. Correct interpretation of the data from such trials depends largely on adequate design and on performing the appropriate statistical analyses. This book provides a useful guide to medical statisticians and others faced with the often difficult problems of designing and analysing clinical trials./a
Biopharmaceutical Applied Statistics Symposium
| Author | : Karl E. Peace |
| Publisher | : Springer |
| Total Pages | : 414 |
| Release | : 2018-08-20 |
| Genre | : Medical |
| ISBN | : 9811078297 |
This BASS book Series publishes selected high-quality papers reflecting recent advances in the design and biostatistical analysis of biopharmaceutical experiments – particularly biopharmaceutical clinical trials. The papers were selected from invited presentations at the Biopharmaceutical Applied Statistics Symposium (BASS), which was founded by the first Editor in 1994 and has since become the premier international conference in biopharmaceutical statistics. The primary aims of the BASS are: 1) to raise funding to support graduate students in biostatistics programs, and 2) to provide an opportunity for professionals engaged in pharmaceutical drug research and development to share insights into solving the problems they encounter.The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. This book is the first of the 3-volume book series. The topics covered include: A Statistical Approach to Clinical Trial Simulations, Comparison of Statistical Analysis Methods Using Modeling and Simulation for Optimal Protocol Design, Adaptive Trial Design in Clinical Research, Best Practices and Recommendations for Trial Simulations in the Context of Designing Adaptive Clinical Trials, Designing and Analyzing Recurrent Event Data Trials, Bayesian Methodologies for Response-Adaptive Allocation, Addressing High Placebo Response in Neuroscience Clinical Trials, Phase I Cancer Clinical Trial Design: Single and Combination Agents, Sample Size and Power for the Mixed Linear Model, Crossover Designs in Clinical Trials, Data Monitoring: Structure for Clinical Trials and Sequential Monitoring Procedures, Design and Data Analysis for Multiregional Clinical Trials – Theory and Practice, Adaptive Group-Sequential Multi-regional Outcome Studies in Vaccines, Development and Validation of Patient-reported Outcomes, Interim Analysis of Survival Trials: Group Sequential Analyses, and Conditional Power – A Non-proportional Hazards Perspective.
Textbook of Clinical Trials in Oncology
| Author | : Susan Halabi |
| Publisher | : CRC Press |
| Total Pages | : 645 |
| Release | : 2019-04-24 |
| Genre | : Mathematics |
| ISBN | : 1351620975 |
There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others
Multiple Testing Problems in Pharmaceutical Statistics
| Author | : Alex Dmitrienko |
| Publisher | : CRC Press |
| Total Pages | : 323 |
| Release | : 2009-12-08 |
| Genre | : Mathematics |
| ISBN | : 1584889853 |
Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c
Mosby's Dictionary of Medicine, Nursing and Health Professions - Revised 3rd Anz Edition
| Author | : Peter Harris |
| Publisher | : Elsevier |
| Total Pages | : 2107 |
| Release | : 2018-08-22 |
| Genre | : |
| ISBN | : 072958691X |
Mosby's Dictionary of Medicine, Nursing & Health Professions has been acclaimed by students and educators for its clarity, comprehensiveness and currency. Now in its third revised edition, a thorough revision of this definitive reference for the Australian and New Zealand region enhances the classic Mosby Dictionary features and offers all of the following: Over 39 000 clear, precise entries, plus encyclopaedic entries of significant terms Over 2000 high quality images and the apt use of tables to demonstrate and clarify More than 30 medical and health specialties represented A detailed colour atlas of anatomy, enhancing the comprehension of anatomical terms Local spelling conventions and phonetic pronunciation guides throughout Fully revised etymologies Comprehensive entries for numerous drugs Valuable appendices, including normal laboratory values for adults and children, units of measurement, nutrition guidelines, assessment guides, immunisation schedules, infection control and herb-drug interactions ONLINE FEATURES: Access to all online resources Regionalised spellchecker Printable colour atlas of human anatomy Image collection offers all images for online viewing 5 comprehensive appendices
Data Monitoring Committees in Clinical Trials
| Author | : Susan S. Ellenberg |
| Publisher | : John Wiley & Sons |
| Total Pages | : 208 |
| Release | : 2003-01-17 |
| Genre | : Mathematics |
| ISBN | : 0470854154 |
There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities. * Provides a practical overview of data monitoring in clinical trials. * Describes the purpose, responsibilities and operation of data monitoring committees. * Provides directly applicable advice for those managing and conducting clinical trials, and those serving on data monitoring committees. * Gives insight into clinical data monitoring to those sitting on regulatory and ethical committees. * Discusses issues pertinent to those working in clinical trials in both the US and Europe. The practical guidance provided by this book will be of use to professionals working in and/or managing clinical trials, in academic, government and industry settings, particularly medical statisticians, clinicians, trial co-ordinators, and those working in regulatory affairs and bioethics.
