A Lethal Inheritance

A Lethal Inheritance
Author: Victoria Costello
Publisher: Prometheus Books
Total Pages: 296
Release: 2012-01-10
Genre: Psychology
ISBN: 161614467X

Every family has secrets; only some secrets are lethal. In Victoria Costello’s family mental illness had been given many names over at least four generations until this inherited conspiracy of silence finally endangered the youngest members of the family, her children. In this riveting story—part memoir, detective story, and scientific investigation—the author recounts how the mental unraveling of her seventeen-year-old son Alex compelled her to look back into family history for clues to his condition. Eventually she tied Alex’s descent into hallucinations and months of shoeless wandering on the streets of Los Angeles to his great grandfather’s suicide on a New York City railroad track in 1913. But this insight brought no quick relief. Within two years of Alex’s diagnosis of paranoid schizophrenia, both she and her youngest son succumbed to two different mental disorders: major depression and anxiety disorder. Costello depicts her struggle to get the best possible mental health care for her sons and herself, treatment that ultimately brings each of them to full recovery. In the process, she discovers new science that explains how clusters of mental illness traverse family generations. Artfully weaving the scientific into the personal, Costello takes a journey to the far reaches of neuroscience and reports back on the startling findings it is yielding about the complex interplay between genes and environment that drives mental illness, and what it now tells us about how parents can trump a lethal inheritance. She shares the results of long-term U.K. and European family studies identifying the earliest signs of mental illnesses that can be passed on from grandparents to parents and grandchildren. She tracks ongoing clinical trials to reverse the courses of these diseases through early intervention with the latest evidence-based treatments and offers brain-healthy choices individuals and families can make to prevent mental illness—freeing future generations to live healthier, happier lives.

The Inheritance

The Inheritance
Author: Niki Kapsambelis
Publisher: Simon and Schuster
Total Pages: 407
Release: 2017-03-07
Genre: Biography & Autobiography
ISBN: 1451697333

This gripping story of the doctors at the forefront of Alzheimer’s research and the courageous North Dakota family whose rare genetic code is helping to understand our most feared diseases is “excellent, accessible...A science text that reads like a mystery and treats its subjects with humanity and sympathy” (Library Journal, starred review). Every sixty-nine seconds, someone is diagnosed with Alzheimer’s disease. Of the top ten killers, it is the only disease for which there is no cure or treatment. For most people, there is nothing that they can do to fight back. But one family is doing all they can. The DeMoe family has the most devastating form of the disease that there is: early onset Alzheimer’s, an inherited genetic mutation that causes the disease in one hundred percent of cases, and has a fifty percent chance of being passed onto the next generation. Of the six DeMoe children whose father had it, five have inherited the gene; the sixth, daughter Karla, has inherited responsibility for all of them. But rather than give up in the face of such news, the DeMoes have agreed to spend their precious, abbreviated years as part of a worldwide study that could utterly change the landscape of Alzheimer’s research and offers the brightest hope for future treatments—and possibly a cure. Drawing from several years of in-depth research with this charming and upbeat family, journalist Niki Kapsambelis tells the story of Alzheimer’s through the humanizing lens of these ordinary people made extraordinary by both their terrible circumstances and their bravery. “A compelling narrative…and an educational and emotional chronicle” (Kirkus Reviews, starred review), their tale is intertwined with the dramatic narrative history of the disease, the cutting-edge research that brings us ever closer to a possible cure, and the accounts of the extraordinary doctors spearheading these groundbreaking studies. From the oil fields of North Dakota to the jungles of Colombia, this inspiring race against time redefines courage in the face of this most pervasive and mysterious disease.

Lethal Inheritance

Lethal Inheritance
Author: Tahlia Newland
Publisher: S & H Teen
Total Pages: 384
Release: 2012
Genre: Young Adult Fiction
ISBN: 9780987323125

On a rescue mission in a mysterious hidden realm, ex-fencing champion Ariel battles treacherous terrain, vicious elementals, and wraith-like demons who feed on fear and want her dead. To defeat the demons and free her mother, she must learn a secret esoteric wisdom to awaken the dormant but potentially explosive power of her mind.Walnut, a quirky old wise man, guides her across stone-strewn plains and wind-swept swamps, past deep ravines and quaint villages, and through a modern city enclosed in a transparent dome. Nick, the powerful Warrior who travels with them, proves a dangerous attraction. His feral energy hits her like a sledgehammer; sometimes it's bliss, but often it's pain. Can Ariel defeat the sadistic demon lord before he kills her and enslaves her mother? The stakes are high, death a real possibility. Fail now, and she fails humanity.

Genetics

Genetics
Author: George Harrison Shull
Publisher:
Total Pages: 698
Release: 1918
Genre: Electronic journals
ISBN:

Genetics accepts contributions that present the results of original research in genetics and related scientific disciplines.

Inheritance, Or, The Vault of Sands

Inheritance, Or, The Vault of Sands
Author: Christopher Paolini
Publisher: Random House
Total Pages: 882
Release: 2013
Genre: Fiction
ISBN: 0552158623

Not so very long ago, Eragon - Shadeslayer, Dragon Rider - was nothing more than a poor farm boy, and his dragon, Saphira, only a blue stone in the forest. Now, the fate of an entire civilization rests on their shoulders.

Mendelian Inheritance in Man

Mendelian Inheritance in Man
Author: Victor A. McKusick
Publisher: JHU Press
Total Pages: 1728
Release: 1998-06-29
Genre: Health & Fitness
ISBN: 9780801857423

The twelfth edition of this classic reference work includes: - More than 2,000 new entries - A total of more than 9,000 entries - New features and enhancement of the familiar old features - Mapping information on more than 4,000 genes of known function - Information on specific point mutations responsible for more than 700 genetic disorders or neoplasms Mendelian Inheritance in Man (MIM) is a genetic knowledgebase that serves clinical medicine and biomedical research, including the Human Genome Project. It aims to be comprehensive (not only complete, but also collated, integrated, and interpreted), authoritative (not only accurate but also sound in its interpretations and judgements), and timely (not only up-to-date but also historically dimensioned). From a review of the eleventh edition, Reproductive Toxicology: "Even the convenience of computer-based forms of MIM cannot eliminate the need for MIM in book form. The preface provides a wonderful synopsis of human genetics. The information contained in this text serves as a concise review for those with a genetics background." From a review of the tenth edition, New England Journal of Medicine: " Victor McKusick] has been for all these years the shepherd of the development of the field of clinical genetics]. Perhaps his most important pragmatic achievement has been the 10 editions of Mendelian Inheritance in Man, which rapidly became and has remained the principal source of information on inherited diseases for all clinical geneticists. "In addition to the erudite entries in the books, the references given with each description represent a magnificent bibliography of clinical genetics. With McKusick's leadership and continued interest in gene mapping, the book also rep-resents an important compen-dium of the location of genes on specific chromosomes. "The book is a magnificent security blanket for the clinical geneticist and should be in the libraries not only of these specialists, but also of all others who see patients with diseases that have genetic components."

Anatomy & Physiology

Anatomy & Physiology
Author: Lindsay Biga
Publisher:
Total Pages:
Release: 2019-09-26
Genre:
ISBN: 9781955101158

A version of the OpenStax text

Transmission and Population Genetics

Transmission and Population Genetics
Author: Benjamin A. Pierce
Publisher: Macmillan
Total Pages: 438
Release: 2006-01-09
Genre: Science
ISBN: 9780716783879

This new brief version of Benjamin Pierce’s Genetics: A Conceptual Approach, Second Edition, responds to a growing trend of focusing the introductory course on transmission and population genetics and covering molecular genetics separately. The book is comprised of following chapters an case studies from Pierce's complete text: 1. Introduction to Genetics 2. Chromosomes and Cellular Reproduction 3. Basic Principles of Heredity 4. Sex Determination and Sex-Linked Characteristics 5. Extensions and Modifications of Basic Principles 6. Pedigree Analysis and Applications INTEGRATIVE CASE STUDY Phenylketonuria: Part I 7. Linkage, Recombination, and Eukaryotic Gene Mapping 8. Bacterial and Viral Genetic Systems 9. Chromosome Variation INTEGRATIVE CASE STUDY Phenylketonuria: Part II 22. Quantitative Genetics 23. Population Genetics and Molecular Evolution INTEGRATIVE CASE STUDY Phenylketonuria: Part III