A Handbook Of Transcription Factors
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| Author | : Timothy R. Hughes |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 310 |
| Release | : 2011-05-10 |
| Genre | : Medical |
| ISBN | : 904819069X |
Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
| Author | : Gregg L. Semenza |
| Publisher | : Oxford Monographs on Medical G |
| Total Pages | : 396 |
| Release | : 1998 |
| Genre | : Health & Fitness |
| ISBN | : 9780195112399 |
Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.
| Author | : Sankar Ghosh |
| Publisher | : CRC Press |
| Total Pages | : 246 |
| Release | : 2006-10-20 |
| Genre | : Medical |
| ISBN | : 1420004271 |
Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is prov
| Author | : Carsten Carlberg |
| Publisher | : Springer |
| Total Pages | : 219 |
| Release | : 2016-06-06 |
| Genre | : Medical |
| ISBN | : 9401777411 |
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule stating that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
| Author | : Timothy R. Hughes |
| Publisher | : Springer |
| Total Pages | : 306 |
| Release | : 2011-05-26 |
| Genre | : Medical |
| ISBN | : 9789048190706 |
Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
| Author | : Pedro Martínez-Gómez |
| Publisher | : MDPI |
| Total Pages | : 626 |
| Release | : 2019-07-11 |
| Genre | : Science |
| ISBN | : 3039211757 |
The development of new plant varieties is a long and tedious process involving the generation of large seedling populations for the selection of the best individuals. While the ability of breeders to generate large populations is almost unlimited, the selection of these seedlings is the main factor limiting the generation of new cultivars. Molecular studies for the development of marker-assisted selection (MAS) strategies are particularly useful when the evaluation of the character is expensive, time-consuming, or with long juvenile periods. The papers published in the Special Issue “Plant Genetics and Molecular Breeding” report highly novel results and testable new models for the integrative analysis of genetic (phenotyping and transmission of agronomic characters), physiology (flowering, ripening, organ development), genomic (DNA regions responsible for the different agronomic characters), transcriptomic (gene expression analysis of the characters), proteomic (proteins and enzymes involved in the expression of the characters), metabolomic (secondary metabolites), and epigenetic (DNA methylation and histone modifications) approaches for the development of new MAS strategies. These molecular approaches together with an increasingly accurate phenotyping will facilitate the breeding of new climate-resilient varieties resistant to abiotic and biotic stress, with suitable productivity and quality, to extend the adaptation and viability of the current varieties.
| Author | : Sharlene Nagy Hesse-Biber |
| Publisher | : Guilford Publications |
| Total Pages | : 754 |
| Release | : 2013-10-15 |
| Genre | : Social Science |
| ISBN | : 1462514804 |
Social researchers increasingly find themselves looking beyond conventional methods to address complex research questions. This is the first book to comprehensively examine emergent qualitative and quantitative theories and methods across the social and behavioral sciences. Providing scholars and students with a way to retool their research choices, the volume presents cutting-edge approaches to data collection, analysis, and representation. Leading researchers describe alternative uses of traditional quantitative and qualitative tools; innovative hybrid or mixed methods; and new techniques facilitated by technological advances. Consistently formatted chapters explore the strengths and limitations of each method for studying different types of research questions and offer practical, in-depth examples.
| Author | : Willow Roberts Powers |
| Publisher | : Rowman Altamira |
| Total Pages | : 156 |
| Release | : 2005 |
| Genre | : Business & Economics |
| ISBN | : 9780759108431 |
This practical handbook aims to clarify the need for and the use of transcription methodology and provides a useful, efficient guide to creating good transcripts for a variety of people using ethnographic methods. Appropriate for varying levels of expertise, it will be an essential tool for transcriptionists, ethnographers, researchers, oral historians, participant observers, and even amateurs who plan to write their family history.
| Author | : Pandurangan, Ashok Kumar |
| Publisher | : IGI Global |
| Total Pages | : 643 |
| Release | : 2022-03-18 |
| Genre | : Medical |
| ISBN | : 1799892603 |
Many chemotherapeutic agents are available in today’s market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.
| Author | : Ralph A. Bradshaw |
| Publisher | : Academic Press |
| Total Pages | : 3188 |
| Release | : 2009-11-03 |
| Genre | : Science |
| ISBN | : 0080920918 |
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
