These proceedings represent the work of contributors to the 15th European Conference on Innovation and Entrepreneurship (ECIE 2020), hosted by Università degli Studi Internazionali di Roma (UNINT), Italy on 17-18 September 2020. The Conference Chair is Prof. Alessandro De Nisco and the Programme Chair is Adjunct Professor Emilio Sassone Corsi, both from Università degli Studi Internazionali di Roma (UNINT), Italy. ECIE is a well-established event on the academic research calendar and now in its 15th year, the key aim remains the opportunity for participants to share ideas and meet the people who hold them. The conference was due to be held at Università degli Studi Internazionali di Roma (UNINT), Italy, but due to the global Covid-19 pandemic it was moved online to be held as a virtual event. The scope of papers will ensure an interesting two days. The subjects covered illustrate the wide range of topics that fall into this important and ever-growing area of research. The keynote presentation is given by Dr. Kenneth A. Grant, from Ryerson University, Toronto, Canada on the topic of The Special Case of the University Entrepreneurial Ecosystem. During the second day of the conference there will be a plenary session entitled NoBORDER INNOVATION - African & European Models of Teaching Entrepreneurship & Innovation. With an initial submission of 251 abstracts, after the double blind, peer review process there are 92 Academic research papers, 15 PhD research papers, 4 Masters Research papers and 4 work-in-progress papers published in these Conference Proceedings. These papers represent research from Bahrain, Belgium, Brazil, Canada, Czech Republic, Denmark, Egypt, Finland, Germany, Ghana, Greece, India, Indonesia, Iran, Iraq, Ireland, Israel, Italy, Japan, Kazakhstan, Lithuania, Mexico, Nigeria, Norway, Peru, Poland, Portugal, Romania, Russia, Russian Federation, Saudi Arabia, Slovakia, South Africa, South Korea, Sweden, Switzerland, Thailand, The Netherlands, Turkey, UK, USA,