8 Day Kidney Preservation
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Author | : Geoffrey Cohen |
Publisher | : |
Total Pages | : 445 |
Release | : 2017-10-20 |
Genre | : |
ISBN | : 9781549980169 |
This book describes a system that was developed between 1975 and 1979 that for the first time succeeded in the preservation of kidneys in vitro for up to 8 days. The system used hypothermic perfusion with a Human Albumin (Plasma Protein Fraction) based perfusate. The study was presented to the University of Liverpool in 1983 as a thesis for the degree of ChM. This book includes the original text and the experimental logs for the study. Both glomerular and tubular injury occurred during storage and this progressed after re-implantation in non viable kidneys. Later work suggested that the concentration of Octanoic Acid in the Plasma Protein Fraction was the most important variable in this experimental system. Bottles of two versions of Plasma Protein Fraction are shown on the first page; the bottle on the left containing 3.6 mmol/l of Octanoic Acid is an example of the batches that were used to make the perfusate for successful 8 day preservation. The bottle on the right is from later production and contains 7.2 mmol/l of Octanoic Acid; no successful preservation beyond 5 days was achieved when this was used to make the perfusate. The success of long duration storage made it possible to show that measurement of the lysosomal enzyme NAG (N-Acetyl-glucosaminidase) in the perfusate could not be used to predict whether stored kidneys that had not been warm injured would function immediately. However, it was shown that perfusate NAG levels might be used to assess the severity of any warm injury.
Author | : Geoffrey Leonard COHEN |
Publisher | : |
Total Pages | : |
Release | : 1982 |
Genre | : |
ISBN | : |
Author | : Michael Marberger |
Publisher | : |
Total Pages | : 376 |
Release | : 1983 |
Genre | : Medical |
ISBN | : |
Author | : Bernard Gijsbert Rijkmans |
Publisher | : |
Total Pages | : 149 |
Release | : 1984 |
Genre | : |
ISBN | : |
Author | : Peter J. Morris |
Publisher | : W.B. Saunders Company |
Total Pages | : 614 |
Release | : 1984 |
Genre | : Medical |
ISBN | : |
This fifth edition of KIDNEY TRANSPLANTATION remains the most comprehensive and definitive text on all aspects of renal transplantation as well as the psychological and ethical issues involved. Almost every chapter has been revised or rewritten by new authors, to incorporate the most essential and up-to-date information.
Author | : D.R. Pegg |
Publisher | : Springer Science & Business Media |
Total Pages | : 413 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9401162670 |
During the past 10 years, there have been many international meetings on the storage of organs prior to transplantation, and several have led to the publication of proceedings; there have also been a number of other books on this subject-. Most of these publications have concentrated on practical clinical aspects of organ preservation and on empirical animal experiments directed towards well-defined clinical objectives. Progress was rapid at first, but it is now generally agreed that there has been little improvement in techniques during the past 5 years, although understanding has certainly increased. In 1980 the Tissue Preservation and Banking Committee of the Transplantation Society decided that a fresh approach to the problem of improving preservation methods was needed: it was decided to hold a conference at which an opportunity would be provided to return to basic principles and to examine some of the advances that have occurred in recent yelns in areas of physiology that might be important for further improvements in preservation. The conference was held in Cambridge, UK, in April 1981 and this book is based upon the papers presented to that meeting and the work of a small discussion group that met after the main meeting. The book starts with six basic review chapters, followed by sections on the effects of ischaemia and anoxia, and on biochemical and pharmacological aspects of hypothermia. Chapters dealing with organ preservation by initial perfusion followed by hypothermia, and by continuous hypothermic perfusion, follow.
Author | : Jurgen Floege |
Publisher | : Elsevier Health Sciences |
Total Pages | : 1313 |
Release | : 2010-11-08 |
Genre | : Medical |
ISBN | : 0323081339 |
Comprehensive Clinical Nephrology provides you with all the tools you need to manage all forms of kidney disease. Drs. Jürgen Floege, Richard J. Johnson, John Feehally and a team of international experts have updated this fourth edition to include hot topics such as treatment of hypertensive emergencies, herbal and over-the-counter medicines and the kidney, neurologic complications of the kidney, and more. This essential resource gives you quick access to today’s best knowledge on every clinical condition in nephrology. Make efficient, informed decisions with just the right amount of basic science and practical clinical guidance for every disorder. Diagnose effectively and treat confidently thanks to more than 1100 illustrations, abundant algorithms, and tables that highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Get coverage of the latest developments in the field with 18 new chapters on the Management of the Diabetic Patient with Chronic Kidney Disease, Treatment of Hypertensive Emergencies, Principles of Drug Dosing and Prescribing of Chronic Kidney Disease, Herbal and Over-the-Counter Medicines and the Kidney, Neurologic Complications of the Kidney, and more. Tap into the experience and expertise of the world’s leading authorities in the field of nephrology. Floege, Johnson, and Feehally give you the information you need to make quick and correct clinical decisions
Author | : Giuseppe Orlando |
Publisher | : Academic Press |
Total Pages | : 1253 |
Release | : 2017-06-08 |
Genre | : Science |
ISBN | : 0128018364 |
Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function
Author | : Ernesto A. Pretto |
Publisher | : Oxford Textbook in Anaesthesia |
Total Pages | : 497 |
Release | : 2015 |
Genre | : Medical |
ISBN | : 0199651426 |
Saving lives through organ transplantation has become increasingly possible thanks to advances in research and care. Today, the complex field of transplantation continues to develop rapidly, fuelled by demographic change and further evolutions in scientific understanding. The Oxford Textbook of Transplant Anaesthesia and Critical Care has been written and edited by pioneers in the field of organ transplantation with an international team of authors, in order to equip anaesthetists and intensivists with the knowledge and training necessary to provide high quality and evidence-based care. The text addresses fundamentals aspects of scientific knowledge, care of the donor patient, transplant ethics and special considerations. Dedicated sections address each of the major organs; kidney, pancreas, liver, heart and lung, intestinal and multivisceral. Within each organ-based section, expert authors explore underlying disease, planning for transplantation, specialized procedures, perioperative and critical care management as well as post-transplant considerations. Focus points for future developments in transplant immunology are also set out, inspiring current practitioners to engage with current clinical research and help participate in the further advancement of the science of transplantation. The print edition of the Oxford Textbook of Transplant Anaesthesia and Critical Care comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.
Author | : Ronald W. Busuttil |
Publisher | : Elsevier Health Sciences |
Total Pages | : 1520 |
Release | : 2014-12-24 |
Genre | : Medical |
ISBN | : 1455753831 |
Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been thoroughly revised to offer you the latest protocols, surgical approaches, and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field, this medical reference book is an ideal single source for authoritative, up-to-date guidance on every imaginable aspect of liver transplantation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access valuable pearls, pitfalls, and insights from Dr. Ronald Busuttil and Dr. Goran Klintmalm, two of the world's preeminent experts in liver surgery. Understand today's full range of transplantation techniques with complete step-by-step descriptions of each, and access the background information and management options for each hepatic disease entity. Take advantage of detailed discussions of everything from pathophysiology and patient and donor selection, to transplantation anesthesia and operative procedures; immunosuppression; postoperative care; and ethical issues. Overcome your toughest challenges in liver transplantation. Many new and thoroughly revised chapters include: Deceased Organ Donation after Cardiac and Brain Death; Liver Transplantation for Non-Alcoholic Steatohepatitis; Extended Criteria Donors; Best Techniques for Biliary and Vascular Reconstruction in Living Donor Transplantation; Small for Size Syndrome; Dual Grafts for Transplantation; Arterial Reconstructions-Pitfalls; Transition of Pediatric Patients to Adulthood; Immunosuppressive Biologic Agents; Long Term Toxicity of Immunosuppressive Therapy; Stem Cell and Liver Regeneration; and Extracorporeal Perfusion for Resuscitation of Marginal Grafts. Stay current in your field and optimize patient outcomes with coverage of the most recent advances in living donor transplantation, pediatric transplantation, and gene and stem cell therapy. Access the latest information on anti-rejection/immunosuppressive drugs, as well as comprehensive discussions of each drug or combination of drugs used to suppress immune system.