2022 Medicinal Chemistry Reviews
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| Author | : Steve Suib |
| Publisher | : Frontiers Media SA |
| Total Pages | : 910 |
| Release | : 2020-04-17 |
| Genre | : |
| ISBN | : 2889635805 |
The Frontiers in Chemistry Editorial Office team are delighted to present the inaugural “Frontiers in Chemistry: Rising Stars” article collection, showcasing the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers featured within this collection were individually nominated by the Journal’s Chief Editors in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of the chemical sciences, and presents advances in theory, experiment and methodology with applications to compelling problems. This Editorial features the corresponding author(s) of each paper published within this important collection, ordered by section alphabetically, highlighting them as the great researchers of the future. The Frontiers in Chemistry Editorial Office team would like to thank each researcher who contributed their work to this collection. We would also like to personally thank our Chief Editors for their exemplary leadership of this article collection; their strong support and passion for this important, community-driven collection has ensured its success and global impact. Laurent Mathey, PhD Journal Development Manager
| Author | : Marc Harrold |
| Publisher | : ASHP |
| Total Pages | : 405 |
| Release | : 2013-01-18 |
| Genre | : Medical |
| ISBN | : 1585283649 |
Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
| Author | : Jie Jack Li |
| Publisher | : John Wiley & Sons |
| Total Pages | : 416 |
| Release | : 2020-06-29 |
| Genre | : Medical |
| ISBN | : 1119607302 |
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
| Author | : Kaplan Test Prep |
| Publisher | : Simon and Schuster |
| Total Pages | : 385 |
| Release | : 2021-11-02 |
| Genre | : Study Aids |
| ISBN | : 1506281761 |
Kaplan’s MCAT Organic Chemistry Review 2022–2023 offers an expert study plan, detailed subject review, and hundreds of online and in-book practice questions—all authored by the experts behind the MCAT prep course that has helped more people get into medical school than all other major courses combined. Prepping for the MCAT is a true challenge. Kaplan can be your partner along the way—offering guidance on where to focus your efforts and how to organize your review. This book has been updated to match the AAMC’s guidelines precisely—no more worrying about whether your MCAT review is comprehensive! The Most Practice More than 350 questions in the book and access to even more online—more practice than any other MCAT organic chemistry book on the market. The Best Practice Comprehensive organic chemistry subject review is written by top-rated, award-winning Kaplan instructors. Full-color, 3-D illustrations from Scientific American, charts, graphs and diagrams help turn even the most complex science into easy-to-visualize concepts. All material is vetted by editors with advanced science degrees and by a medical doctor. Online resources, including a full-length practice test, help you practice in the same computer-based format you’ll see on Test Day. Expert Guidance High-yield badges throughout the book identify the top 100 topics most tested by the AAMC. We know the test: The Kaplan MCAT team has spent years studying every MCAT-related document available. Kaplan’s expert psychometricians ensure our practice questions and study materials are true to the test.
| Author | : Victor E. Marquez |
| Publisher | : CRC Press |
| Total Pages | : 566 |
| Release | : 2021-11-15 |
| Genre | : Medical |
| ISBN | : 1000462943 |
The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students
| Author | : Nouri Neamati |
| Publisher | : John Wiley & Sons |
| Total Pages | : 710 |
| Release | : 2011-08-10 |
| Genre | : Science |
| ISBN | : 1118015363 |
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
| Author | : David A. Williams |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 1136 |
| Release | : 2002 |
| Genre | : Medical |
| ISBN | : 0683307371 |
This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
| Author | : B.E. Maryanoff |
| Publisher | : Elsevier |
| Total Pages | : 338 |
| Release | : 1999-04-01 |
| Genre | : Science |
| ISBN | : 0080526373 |
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
| Author | : A.K. Ganguly |
| Publisher | : CRC Press |
| Total Pages | : 163 |
| Release | : 2021-09-12 |
| Genre | : Medical |
| ISBN | : 1000437280 |
Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 566 |
| Release | : 2020-08-26 |
| Genre | : Science |
| ISBN | : 0128210184 |
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Annual Reports in Medicinal Chemistry series
